New Study Signals Wheat-Autism Link


As the autism epidemic continues to accelerate, one of the least well known contributing factors goes mostly unnoticed: wheat consumption.

A new study published in the open access journal PLoS is reinvigorating the debate over what are the primary causes of the accelerating autism epidemic. Whereas too many within the conventional medical establishment, failing to identify a singular cause, apathetically label the condition "idiopathic," i.e. cause unknown, or worse, "caused by unknown defective genes," there is a growing awareness that a multitude of environmental factors including vaccines, chemical exposures, C-sections, antibiotics, genetically modified food, and food intolerances are essential in both understanding and treating this disturbing affliction.

The point therefore is not to prove one thing the cause (e.g. autism genes. vaccines), as if it were strictly some kind of academic sport or past time, but rather, to acknowledge possible contributing factors, and eliminate them whenever possible as a precaution.

The new study titled, "Markers of Coeliac Disease and Gluten Sensitivity in Children with Autism," explores the possible association between gluten sensitivity and autism, which previous research has confirmed only inconsistently.

They described their aim as follows: "To assess immune reactivity to gluten in paediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and coeliac disease."

They discovered that children with autism had significantly higher levels of IgG antibodies to gliadin, the primary immunotoxic protein in wheat, compared with healthy controls. They also found that the IgG anti-gliadin antibody response was significantly greater in autistic children with gastrointestinal symptoms in comparison to those without them. The elevated IgG antibodies indicate: 1) that their immune systems are identifying gliadin proteins as "other." 2) that gliadin is not being properly broken down through digestive processes and are entering the blood through a compromised intestinal tract ("leaky gut").

It has been theorised that when the immune system forms antibodies against gliadin, they cross react with self-structures within the nervous system. Known as molecular mimicry, this breakdown of immunological self-tolerance can contribute to a wide range of neurological problems including neuropathy, ataxia, seizures, and neurobehavioural changes including mania, schizophrenia and autism. Anti-gliadin antibodies are therefore a possible cause of autoimmune neurological damage. One study published in the Journal of Immunology in 2007 found that anti-gliadin antibodies cross-react with the neurological protein class known as synapsin I, providing a molecular mechanism behind how an immune reaction to gliadin could contribute to neurological degeneration.


Beyond Coeliac Disease: Wheat Causes Far More Harm Than Commonly Understood

When the researchers looked at levels of coeliac-disease-specific blood markers (i.e. antibodies to deamidated gliadin and TG2), they did not differ between patients and controls. Moreover, there was no observed association between the HLA-DQ2 genetic locus of coeliac disease susceptibility and increased anti-gliadin antibodies. This is an important finding, as many look upon wheat intolerance or sensitivity as a rare disorder without a clearly defined mechanism of action like coeliac disease. They would rather not believe that wheat, which is a glorified grain in wealthier countries, could contribute to a wide range of diseases. Our project, for instance, has identified over 200 potential adverse health effects of gluten consumption. One does not therefore have to have classically defined coeliac disease, or "wheat allergy," to experience adverse effects associated with gluten-grain consumption.

The authors of the study concluded:

A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in coeliac disease. The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.

Scientists are cautious, and they should be. For those who are suffering with an autistic child or family member, however, a gluten free diet might be worth exploring now, even if the link is only considered tentative from the perspective of the peer-reviewed clinical literature.

www.greenmedinfo.com





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